tco-peg-3-tco

TCO-PEG3-TCO is a PEG-based linker commonly used in PROTAC development to connect two essential ligands within a single molecule. By facilitating the formation of bifunctional degraders, TCO-PEG3-TCO linker supports targeted protein degradation through the ubiquitin–proteasome system, enabling precise modulation of intracellular protein levels.

Amino-bis-PEG3-TCO is a three-unit cleavable polyethylene glycol (PEG) linker utilized in the synthesis of antibody-drug conjugates (ADCs) [1].

DBCO-PEG3-TCO is a non-cleavable three-unit polyethylene glycol (PEG) linker employed for synthesizing antibody-drug conjugates (ADCs) [1].

Gly-Gly-Gly-PEG3-TCO is a cleavable three-unit polyethylene glycol (PEG) linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

(S)-TCO-PEG3-amine is a PEG-based linker for PROTACs, joining two essential ligands to facilitate selective protein degradation via the ubiquitin-proteasome system within cells.

TCO-PEG3-acid, a PEG-based linker for PROTACs, joins two essential ligands crucial for forming PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

TCO-PEG3-alcohol is a PEG-based linker for PROTACs that connects two essential ligands, facilitating the formation of PROTAC molecules and enabling selective protein degradation through the ubiquitin-proteasome system within cells.

TCO-PEG3-amide-C3-triethoxysilane is a polyethylene glycol (PEG)-based linker used in the synthesis of proteolysis targeting chimeras (PROTACs) [1].

TCO-PEG3-amine is a PEG-based linker for PROTACs that joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

TCO-PEG3-Biotin is a PEG-based cleavable ADC linker for synthesising antibody-drug conjugates (ADCs). Its TCO moiety undergoes click chemistry iEDDA reactions with molecules containing tetrazine groups.

TCO-PEG3-maleimide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

TCO-PEG3-NHS ester is a PEG-based linker for PROTACs that joins two essential ligands, crucial for PROTAC molecule formation, enabling selective protein degradation via the ubiquitin-proteasome system [in cells].

TCO-PEG3-oxyamine is a PEG-based linker for PROTACs that joins two essential ligands, facilitating selective protein degradation through the ubiquitin-proteasome system within cells.

DSPE-PEG(2000)-TCO is a polyethylene glycol-modified derivative of DSPE for preparing lipid nanoparticles (LNPs), whose TCO moiety undergoes bioorthogonal IEDDA reactions with triazine rings.

TCO-PEG3-CH2-aldehyde, a cleavable 3-unit PEG ADC linker, is employed in the construction of antibody-drug conjugates (ADCs) [1]. This compound serves as a click chemistry reagent and features a TCO group capable of participating in an inverse electron demand Diels-Alder reaction (iEDDA) with molecules that contain Tetrazine groups.

TCO-PEG3-aldehyde, a cleavable 3-unit PEG ADC linker, is used in the synthesis of antibody-drug conjugates (ADCs) [1]. This click chemistry reagent contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.

Me-Tet-PEG3-NH2 hydrochloride is an ADC linker containing three PEG units. This compound, with its tetrazine group, specifically undergoes an inverse electron demand Diels-Alder reaction (iEDDA) with compounds bearing a TCO group.