t5224

T-5224 is a transcription factor c-Fos/AP-1 inhibitor that specifically inhibits the DNA-binding activity of c-Fos/c-Jun without affecting other transcription factors.

2-Hydroxyhexanoic acid (2-Hydroxycaproic acid) is a branched-chain alpha-keto acid that has been reported in normal human blood and in normal amniotic fluid. It has been found that 2-Hydroxyhexanoic acid is the most significant metabolite found in the CSF of patients infected with Nocardia.

T-5224-d8 is the deuterium-labeled form of T-5224. T-5224 acts as a selective inhibitor of the transcription factor c-Fos/activator protein (AP)-1, demonstrating anti-inflammatory properties. It specifically inhibits the DNA binding activity of c-Fos/c-Jun without affecting the binding activity of other transcription factors. T-5224 also suppresses the transcriptional upregulation of IL-1β-induced Mmp-3, Mmp-13, and Adamts-5.