spiramycin

Spiramycin (Rovamycin) is a macrolide antibiotic produced by Streptomyces ambofaciens, effective against gram-positive aerobic pathogens, N. gonorrhoeae, and staphylococci, and is used to treat infections caused by bacteria and Toxoplasma gondii.

Acetylspiramycin (Spiramycin B) targets 50S ribosome to inhibit protein synthesis.

4"-(2-(p-Chlorophenyl)acetoxyl)spiramycin (Compound 2d) is a broad-spectrum anti-coronavirus agent that targets the frameshifting element (FSE). It inhibits HCoV-OC43 and HCoV-229E with EC50 values of 0.85 μM and 1.45 μM, respectively. This compound exhibits a dual-target mechanism by acting on both viral FSE RNA and host DIS3L2.

Spiramycin III is an antibiotic within the erythromycin/carbomycin group of compounds.

Spiramycin (Standard) is the standard substance of Spiramycin, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Spiramycin (Rovamycin) is a macrolide antibiotic produced by Streptomyces ambofaciens. The drug is effective against gram-positive aerobic pathogens, N. gonorrhoeae, and staphylococci. It is used to treat infections caused by bacteria and Toxoplasma gondii.

Spiramycin hexanedioate (Rovamycin) is a macrolide antibiotic produced by Streptomyces ambofaciens, exhibiting antibacterial, anti-Toxoplasma, and antiparasitic properties. The structure of Spiramycin hexanedioate comprises 16 lactone rings and is adorned with three sugars: mycaminose, forosamine, and mycarose.

Neospiramycin is a major metabolite of Spiramycin I.

Neospiramycin I is a macrolide antibiotic and derivative of spiramycin I.1It is active against the macrolide-sensitive KB210, but not the macrolide-resistant KB224, strain ofS. aureus(MICs = 3.12 and >100 μg/ml, respectively), as well asB. cereus,B. subtilis,M. luteus,E. coli, andK. pneumoniae(MICs = 1.56, 3.12, 3.12, 0.2, 50, and 12.5 μg/ml, respectively). Neospiramycin I binds toE. coliribosomes with an IC50value of 1.2 μM. It protects against mortality in a mouse model ofS. pneumoniaetype III infection (ED50= 399.8 mg/kg).2

Antibacterial agent 193 (Compound 2n) is a spiramycin A monobenzyl derivative exhibiting antibacterial activity against the plant pathogen Rhizoctonia solani, with an IC50 value of 5.25 μg/mL.