sn-glycerol 3-phosphate

sn-Glycerol 3-phosphate, produced by the reduction of dihydroxyacetone phosphate by NADH formed during glycolysis of the cytoplasmic glycerol 3-phosphate dehydrogenase pathway.

sn-Glycerol 3-phosphate lithium is synthesized via the cytosolic glycerol 3-phosphate dehydrogenase pathway, involving the conversion of dihydroxyacetone phosphate to sn-Glycerol 3-phosphate using NADH generated during glycolysis.

(Rac)-sn-Glycerol 3-phosphate sodium, an A-site substrate analogue, strongly inhibits reaction rates between indole and nucleophilic indole analogues with E(A-A) when bound to the A-site [1].

1,2-Dipalmitoyl-sn-glycerol 3-phosphate (a phosphatidic acid) is a human endogenous metabolite.

1,2-Dipalmitoyl-sn-glycerol 3-phosphate sodium, a phosphatidic acid, is an endogenous human metabolite.

1-Palmitoyl-sn-glycerol 3-phosphate (1-P-GPA), an endogenous metabolite, is used in research on non-alcoholic fatty liver disease [1].

1-Stearoyl-sn-glycerol 3-phosphate sodium, a biologically active phospholipid, plays a crucial role in regulating cell motility, proliferation, invasion, survival, and the production of growth factors through interactions with G protein-coupled receptors (GPCR). Synthesized during the formation of membrane phospholipids, this compound typically has a low plasma concentration (approximately 100nM) and originates from various cell types, including activated platelets, epithelial cells, leukocytes, neuronal cells, and tumor cells. Its distinctive structure features stearic acid at the sn-1 position and a hydroxyl group at the sn-2 position.

1-Myristoyl-2-hydroxy-sn-glycero-3-phosphate sodium is a salt form compound.1-Myristoyl-2-hydroxy-sn-glycero-3-phosphate is a lipid and endogenous metabolite related to LPA (lysophosphatidic acid).

1-Arachidonoyl-2-hydroxy-sn-glycero-3-PA is a phospholipid that contains arachidonic acid at the sn-1 position, serving as a precursor to 1-Monoarachidin. It binds with the LPA2/EDG4 receptor and can inhibit the secretion of TNF-α and IL-6 induced by LPS in wild-type dendritic cells but does not affect Lpa2-/- dendritic cells. Additionally, it reduces the differentiation of HT-29 human colon cancer cells into goblet cells in the presence of sodium butyrate.

1-Arachidonoyl-2-hydroxy-sn-glycero-3-PA (sodium) [1-Arachidonoyl-sn-glycerol 3-phosphate (sodium)] is a phospholipid containing arachidonic acid at the sn-1 position. It binds to the LPA2/EDG4 receptor with an EC50 of 10 nM and is present in the rat brain, representing 37% of arachidonic acid lysophosphatidic acid species. This compound serves as a precursor to 1-arachidonoyl-sn-glycerol and inhibits the secretion of TNF-α and IL-6 from dendritic cells stimulated by wild-type LPS. Additionally, 1-arachidonoyl-2-hydroxy-sn-glycero-3-PA (sodium) can suppress the differentiation of HT-29 colon cancer cells into goblet cells in the presence of sodium butyrate.

1-Palmitoyl Lysophosphatidic Acid (sodium salt) is an LPA derivative and endogenous metabolite, suitable for related research in the field of life sciences.

iGP-1 is a mitochondrial sn-glycerol 3-phosphate dehydrogenase (mGPDH) inhibitor that can be used to study obesity.

iGP-5 is a cell-permeable mitochondrial sn-Glycerol 3-phosphate dehydrogenase (mGPDH) inhibitor.

1,2,3-Trioctanoyl-rac-glycerol-13C3 is intended for use as an internal standard for the quantification of 1,2,3-trioctanoyl-rac-glycerol by GC- or LC-MS. 1,2,3-Trioctanoyl-rac-glycerol is a triacylglycerol that contains octanoic acid at the sn-1, sn-2, and sn-3 positions. Dietary administration of 1,2,3-trioctanoyl-rac-glycerol increases hippocampal levels of the glycolytic metabolites glucose 6-phosphate, fructose 6-phosphate, and β-hydroxybutyrate and the seizure threshold in the 6 Hz psychomotor seizure test in mice.1 Formulations containing 1,2,3-trioctanoyl-rac-glycerol have been used in cosmetic products as thickening and skin-conditioning agents.

Cyclic Phosphatidic Acids (cPAs) are naturally occurring lysophosphatidic acid (LPA) analogs, characterized by a 5-membered ring formed between the sn-2 hydroxy group and the sn-3 phosphate. Carba-derivatives of cPA (ccPA) modify the sn-2 (2-ccPA) or sn-3 (3-ccPA) linkage, hindering the conversion of cPA into LPA. Oleoyl 3-Carbacyclic Phosphatidic Acid (3-ccPA 18:1) incorporates the 18:1 fatty acid oleate at the sn-1 position on the glycerol backbone, acting as a cyclic LPA analog. This compound, at a concentration of 25 μM, blocks MM1 cells' transcellular migration through mesothelial cell monolayers induced by fetal bovine serum (by 90.1%) or LPA (by 99.9%), without impeding cell proliferation. Additionally, 3-ccPA 18:1, in the 0.1-1.0 μM range, notably suppresses autotaxin, which plays a vital role in various cancer cell behaviors including survival, growth, migration, invasion, and metastasis.