slamf-5

CD84, also called SLAMF5, is a member of the CD2 subgroup of the immunoglobulin receptor superfamily. Members of this CD2 subgroup mediate signal transduction through the interaction of its immunoreceptor tyrosine-based switch motifs (ITSM) in the intracellular region and the SH2 domain of adaptor molecules SAP (SLAM-associated protein) and EAT-2 (EWS-activated transcript 2), and accordingly modulate both adaptive and innate immune responses. CD84 expression has been documented on several hematopoietic cell types, including monocytes, macrophages, dendritic cells, B lymphocytes, and platelets. Activation of cell surface CD84 initiates a signaling cascade involving its intra-cytoplasmic tyrosine residues that results in Bcl-2 upregulation, which in turn enhances cell survival. Either immunoneutralization or blockade of CD84 with a CD84 extracellular domain protein fragment induces cell death in vitro and in vivo.

Expression system: HEK293 Cells
Length: 22-220, Partial
Activity: Not Tested

Expression system: HEK293 Cells
Length: 22-220, Partial
Activity: Not Tested

Expression system: HEK293 Cells
Length: 22-225, Partial
Activity: Not Tested

Expression system: HEK293 Cells
Length: 1-221, Partial
Activity: ELISA

Expression system: HEK293 Cells
Length: 1-225, Partial
Activity: Not Tested