simvastatin

Simvastatin (MK 733) is an HMG-CoA reductase inhibitor (Ki=0.2 nM) with oral activity. Simvastatin has hypolipidemic activity, inhibits hepatic production of cholesterol, and is also used for the prevention of cardiovascular disease.

2'-Ethyl Simvastatin is a Mevinolin analog with HMG-CoA reductase inhibition.

Simvastatin-D6 (Standard) is a reference standard of Simvastatin-D6 intended for quantitative analysis, quality control, and related biochemical research applications.

Anhydrosimvastatin (Dehydro simvastatin) is an impurity of Simvastatin. Simvastatin is an HMG-CoA reductase inhibitor.

Simvastatin acid ammonium (Tenivastatin ammonium) is an HMG-CoA reductase (HMGCR) inhibitor that reduces cholesterol production by competitively inhibiting HMG-CoA reductase (3-hydroxy-methylglutaryl coenzyme).

Tenivastatin (Simvastatin acid) is an anti-hyperlipidemic HMG-CoA reductase inhibitor that inhibits the production of reactive oxygen species (ROS) and can be used in the study of primary hyperlipidemia.

3'-Hydroxy simvastatin is a metabolite of Simvastatin, an orally active competitive inhibitor of HMG-CoA reductase (HMGCR) with a Ki of 0.2 nM.

Simvastatin acid (Tenivastatin) calcium hydrate is an orally active inhibitor of HMG-CoA reductase (HMGCR) and also inhibits indoxyl sulfate-mediated reactive oxygen species (ROS) production.

(Rac)-3′-Hydroxy Simvastatin, a metabolite of Simvastatin, acts as a competitive inhibitor of HMG-CoA reductase, demonstrating a K i value of 0.2 nM.

Simvastatin Acyl-β-D-glucuronide, a metabolite formed from Simvastatin, acts as a competitive inhibitor of HMG-CoA reductase, showcasing a potent Ki of 0.2 nM.

Simvastatin-D3 is the deuterated form of Simvastatin. Simvastatin (T0687) (MK 77333) acts as a competitive inhibitor of HMG-CoA reductase (HMGCR) with a Ki of 0.2 nM and is orally active. It reduces cholesterol synthesis and lowers blood cholesterol levels. Additionally, Simvastatin (T0687) demonstrates antiproliferative effects on cancer cells and can induce apoptosis (apoptosis).

Simvastatin EP Impurity A-D6 Sodium Salt is a deuterated compound of Simvastatin EP Impurity A Sodium Salt. Simvastatin EP Impurity A Sodium Salt (T0687L) has a CAS number of 101314-97-0.

Simvastatin (Standard) is the standard substance of Simvastatin, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Simvastatin (MK 733) is an HMG-CoA reductase inhibitor (Ki=0.2 nM) with oral activity. Simvastatin has hypolipidemic activity, inhibits hepatic production of cholesterol, and is also used for the prevention of cardiovascular disease.

Simvastatin-D11 (2,2-Dimethylbutyrate-D11) (Standard) is a reference standard of Simvastatin-D11 (2,2-Dimethylbutyrate-D11) intended for quantitative analysis, quality control, and related biochemical research applications.

Simvastatin Hydroxy Acid-[D6] Ammonium Salt (Standard) is a reference standard of Simvastatin Hydroxy Acid-[D6] Ammonium Salt intended for quantitative analysis, quality control, and related biochemical research applications.

4-Acetylsimvastatin is acetylated simvastatin. Simvastatin is a competitive inhibitor of HMG-CoA reductase (Ki: 0.2 nM).

Lapaquistat acetate (TAK-475) is a squalene synthase inhibitor with potential anti-inflammatory activity. It mitigates statin-induced toxicity in human skeletal muscle cells and protects guinea pigs from simvastatin-induced myotoxicity, useful for research on hypercholesterolemia and HMG-CoA reductase deficiency.

Dodecenylsuccinic anhydride (DDSA) can be grafted with collagen hydrogels as a hydrophobic wound dressing to incorporate simvastatin, which has potential application in the treatment of ulcers and prevention of wound infection.