shp2-d26

SHP2-D26 is a highly potent and effective SHP2 degrader that induces targeted SHP2 protein degradation through simultaneous binding to VHL-1 and SHP2, with degradation strictly dependent on neddylation and proteasome activity, thereby providing a powerful chemical biology tool for dissecting SHP2-driven signaling networks in cancer and immune regulation.

SHP2-IN-43 (Compound 5) is an SHP2 inhibitor with an IC50 of 98.7 nM. It can be used as a PROTAC target protein ligand in the synthesis of SHP2-D26.

SHP2 protein degrader-2 (SHP2-D26), a PROTAC degrader targeting the SHP2 protein, effectively reduces its expression across various cancer cell types [1].