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Results for "
scn2a
" in TargetMol Product Catalog- Inhibitors & Agonists3
- Recombinant Protein2
TCS PrP Inhibitor 13
5-(4-Nitrophenyl)-2-Phenyl-4H-Pyrazol-3-One
T2345034320-83-7
TCS PrP Inhibitor 13 (5-(4-Nitrophenyl)-2-Phenyl-4H-Pyrazol-3-One) is an antiprion agent inhibiting protease-resistant prion protein (PrP-res) accumulation.
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1-(4-Methoxyphenyl)-3-methyl-1H-pyrazol-5(4H)-one
T20173760798-06-3
1-(4-Methoxyphenyl)-3-methyl-1H-pyrazol-5(4H)-one (Compound 2) exhibits antiprion activity in ScN2a and F3 cells, with IC50 values of 13 nM and 25 nM, respectively.
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ARN1468
T612561381459-14-8
ARN1468 (compound 5) is a highly effective orally active inhibitor of serpins. Inhibition of serpins activity by ARN1468 enables release of proteases, thereby reducing prion accumulation. ARN1468 demonstrates pronounced anti-prion effects in ScGT1 RML, ScGT1 22L, ScN2a RML, and ScN2a 22L cell lines, with EC 50 values of 8.64, 19.3, 11.2, and 6.27 μM [1].
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