scn2a

TCS PrP Inhibitor 13 (5-(4-Nitrophenyl)-2-Phenyl-4H-Pyrazol-3-One) is an antiprion agent inhibiting protease-resistant prion protein (PrP-res) accumulation.

1-(4-Methoxyphenyl)-3-methyl-1H-pyrazol-5(4H)-one (Compound 2) exhibits antiprion activity in ScN2a and F3 cells, with IC50 values of 13 nM and 25 nM, respectively.

Elsunersen is an antisense oligonucleotide designed to selectively reduce the expression of the SCN2A gene. It is utilized in the study of SCN2A developmental and epileptic encephalopathy (SCN2A-DEE), a severe and fatal monogenic epilepsy disorder caused by variations in the SCN2A gene.

Elsunersen sodium is an antisense oligonucleotide that selectively reduces the expression of the SCN2A gene. It is used in the study of SCN2A developmental and epileptic encephalopathy (SCN2A-DEE), a severe and life-threatening monogenic epilepsy disorder caused by variations in the SCN2A gene.

ARN1468 (compound 5) is a highly effective orally active inhibitor of serpins. Inhibition of serpins activity by ARN1468 enables release of proteases, thereby reducing prion accumulation. ARN1468 demonstrates pronounced anti-prion effects in ScGT1 RML, ScGT1 22L, ScN2a RML, and ScN2a 22L cell lines, with EC 50 values of 8.64, 19.3, 11.2, and 6.27 μM [1].