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TPP1 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 60.7 kDa and the accession number is AAH14863.1.

Expression system: HEK293 Cells
Length: 25-381, Full Length of Mature Protein
Activity: Not Tested

TPP-1 Acetate(2426685-25-6 Free base) is a peptide molecule that can be used in life science related research.

TPP-1, a peptide inhibitor, targets the interaction between programmed cell death protein 1 (PD-1) and its ligand (PD-L1), binding specifically to PD-L1 with a dissociation constant (Kd) of 94.67 nM. At a concentration of 20 µM, TPP-1 effectively counteracts the PD-L1-induced suppression of IFN-γ production in anti-CD3-stimulated isolated human CD4+ T cells. Furthermore, TPP-1 demonstrates significant efficacy in reducing tumor volume in a mouse xenograft model of HL-60 leukemia. This model involved HL-60 cells co-cultured with anti-CD3-activated isolated human CD4+ T cells, with TPP-1 administration at a dosage of 4 mg/kg showing notable antitumor activity.

Expression system: Baculovirus Insect Cells
Length: 1-562, Full Length
Activity: Not Tested

TPP-1, a potent inhibitor of the PD-1/PD-L1 interaction, exhibits high affinity for PD-L1, with a dissociation constant (K D) of 95 nM. It effectively inhibits human tumor growth in vivo by reactivating T-cell function [1].