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- Inhibitors & Agonists1
SB334867 HCl
T4372249889-64-3
SB-334867 (SB 334867A) is a potent, selective, and blood-brain barrier permeable antagonist of the orexin-1 (OX1) receptor, demonstrating significant selectivity against OX2 (pKb=7.4), and exhibiting 100-fold selectivity over 5-HT2B and 5-HT2C, with pKi values of 5.4 and 5.3, respectively [1]. This compound effectively reduces ethanol consumption and obstructs the development of morphine-induced sensitization to locomotor activity in vivo [2] [3].
- $970
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