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sb-203186

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SB-203186 hydrochloride
T23310207572-69-8
SB 203186 hydrochloride is a potent 5-HT4 receptor antagonist
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SB 203186
T212733135938-17-9
SB 203186 is an exceptionally potent and highly selective indole-based 5-HT4 receptor antagonist (Ki = 0.2 nM). It completely blocks 5-HT4-mediated depolarization and cholinergic signal amplification in both central and peripheral neurons at picomolar levels, widely used to investigate the pathogenesis of gastrointestinal smooth muscle motility disorders and arrhythmias.
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