sar-131675

(Rac)-SAR131675 is an effective and specific VEGFR-3 inhibitor. It inhibited VEGFR-3 tyrosine kinase activity (IC50: 20 nmol/L) and VEGFR-3 autophosphorylation (IC50: 45 nmol/L) in HEK cells, respectively. SAR131675 is highly specific for VEGFR-3 versus 107 receptors, enzymes, ion channels, and 65 kinases. SAR131675 is a highly specific VEGFR-3-TK inhibitor with significant antitumoral and antimetastatic activities in vivo through inhibition of lymphangiogenesis and TAM invasion.

SAR131675 is a potent and selective VEGFR3 inhibitor with an IC50 of 23 nM.

(S)-SAR131675 is the S-enantiomer of SAR131675, a potent and selective VEGFR3 inhibitor that also serves as a click chemistry reagent.