s1pr2

BAF312 (Siponimod (BAF-312)), a next-generation S1P receptor modulator, is specific for S1P1 and S1P5 receptors with EC50 of 0.39 nM and 0.98 nM, respectively. The specificity of BAF312 for S1P1 and S1P5 receptors exhibits >1000-fold over S1P2, S1P3 and S1P4 receptors.

ML-031 activated S1P2 with an EC50 value of 1 μM in an S1P reporter assay.

CYM-5520 is a noncompetitive allosteric agonist of S1P2

CYM-5478 is a potent and selective S1P2 agonist that significantly increases the viability of C6 cells in a dose-dependent manner at concentrations above 100 nM under nutrient-deprivation stress (produced by serum-starvation).

L-threo Lysosphingomyelin (d18:1) (L-threo-Sphingosylphosphorylcholine) is a naturally occurring bioactive sphingolipid that functions as a potent agonist for S1P receptors, with EC50 values of 19.3, 131.8, and 313.3 nM for hS1P1, hS1P3, and hS1P2, respectively.

Siponimod (BAF-312) hemifumarate, a selective and potent modulator of sphingosine-1-phosphate (S1P) receptors, can be used in the study of multiple sclerosis (MS).

XAX-162 is an agonist of Sphingosine 1-phosphate receptor 2 (S1PR2)