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Results for "
rubone
" in TargetMol Product Catalog- Inhibitors & Agonists2
- Natural Products2
2'-Hydroxy-2,4,4',5,6'-pentamethoxychalcone
T2474473694-15-2
Rubone (2'-Hydroxy-2,4,4',5,6'-pentamethoxychalcone), a natural product and a modulator of miR-34a (microRNA-34), upregulates miR-34a expression in a p53-dependent manner, which in turn downregulates the expression of downstream targets Bcl-2, cyclin-D1, CDK6, SIRT1, and FOXP1, thereby inhibiting tumor growth and reversal of hepatocellular carcinoma (HCC) and chemoresistance in prostate cancer.
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Derrubone
TN833622044-58-2
Derrubone, an isoflavone natural product derived from Derris robusta, is considered an effective Hsp90 inhibitor. It binds strongly to the CTD of Hsp90α and induces the degradation of tau proteins, which may be viewed as a potential treatment approach for Alzheimer's disease (AD).
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