rocaglamide

Rocaglamide (Roc-A), isolated from the genus Aglaia, can be used to treat coughs, injuries, asthma, and inflammatory skin diseases. It is a potent inhibitor of NF-κB activation in T-cells.

(+)-Rocaglamide is a natural alkaloid, widely used in biochemical experiments and drug synthesis research.

Didesmethylrocaglamide is a and selective small molecule inhibitor of the eukaryotic translation initiation factor 4A (eIF4A) that effectively blocks the protein translation machinery to exert robust anti-proliferative and pro-apoptotic activities against malignant peripheral nerve sheath tumors and various sarcoma lineages.

Aglafoline inhibits in a concentration-dependent manner the aggregation and ATP release reaction induced in washed rabbit platelets by PAF (platelet-activating factor). The IC50 values of Aglafoline on PAF (3.6 nM)-induced platelet aggregation were about 50 μM.

3'-Hydroxyrocaglamide has insecticidal activity.

C-3'-Methoxyrocaglamide has insecticidal activity.

Desmethylrocaglamide is a novel inducer of cellular differentiation using HL-60 promyelocytic cells, it may be a drug for the prevention and therapy of cancer. It also has insecticidal activity.

Rocagloic acid, a rocaglamide derivative sourced from Aglaia elliptifolia fruit, exhibits significant cytotoxicity [1].