retin3

RET-IN-3 is a RETV804M kinase inhibitor with potential anticancer activity for the study of non-small cell lung cancer.

Phloretin 3',5'-Di-C-glucoside is a useful organic compound for research related to life sciences and the catalog number is T124963.

RET-IN-30 (Compound 28) is a RET inhibitor that exhibits inhibitory activity against both wild-type RET and some of its mutants. It is capable of inhibiting the proliferation of A549 cells and demonstrates antitumor properties.

RET-IN-31 (Compound 13) is an orally active, selective RET inhibitor with IC50 values of 1.4 nM, 1.9 nM, and 3.8 nM for RETWT, RETV804L, and RETV804M, respectively. It also inhibits hERG and Cytochrome P450, with IC50 values of 13.6 μM, 7.9 μM, 12.8 μM, 16.9 μM, 8.9 μM, and 13.0 μM for CYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP3A4-M, and CYP3A4-T, respectively. RET-IN-31 exhibits anticancer properties against cancers driven by activated RET mutations and gene fusions.

(Rac)-Hesperetin 3'-O-β-D-glucuronide is a biochemical reagent used in glycoscience research. Glycoscience examines the structure, synthesis, biology, and evolution of sugars, encompassing carbohydrate chemistry, glycan formation and degradation enzymology, protein-glycan interactions, and the role of glycans in biological systems. This field is closely linked to fundamental research, biomedicine, and biotechnology.