reticuline

Reticuline is an anti-inflammatory and antihypertensive natural product that reduces JAK2/STAT3 and NF-κB phosphorylation levels, inhibits TNF-α and IL-6 mRNA expression, thereby alleviating oedema in rats.

(R)-Reticuline is a natural alkaloid that can be catalyzed by the microsomal P-450 system in plants and animals for conversion to Salutaridine, which is involved in endogenous morphine synthesis. The isomer of (R)-Reticuline is Reticuline. Reticuline inhibits the JAK2/STAT3 and NF-κB signaling pathways, and also inhibits the mRNA expression of TNF-α and IL-6, with anti-inflammatory effects.

(±)-Reticuline (compound 3f), a natural product extracted from Peumus boldus Molina, serves as a precursor for the synthesis of S-Reticuline [1].

Norreticuline is a potential adrenoceptor-α/β agonist and CYP2D6 and D2 receptor inhibitor for the study of neurodegenerative diseases.

1,2-Dehydroreticulinium reductase (NADPH) (EC 1.5.1.27) reduces 1,2-dehydroreticulinium ion to (R)-reticuline.