rat α2b-adrenoceptor

Fiduxosin is a selective and potent α1-adrenoceptor antagonist with inhibitory effects on α1a-adrenoceptor, α1b-adrenoceptor and α1d-adrenoceptor, with Ki values of 0.160 nM, 24.9 nM and 0.920 nM, respectively. Fiduxosin can be used for the treatment of benign prostatic hyperplasia.

RS-79948-197 hemihydrate is a non-imidazoline α2-adrenoceptor antagonist. It exhibits Kd values of 0.42 nM, 0.18 nM, and 0.19 nM for rat α2A, α2B, and α2C receptors, respectively, and 0.60 nM, 0.46 nM, and 0.77 nM for human α2A, α2B, and α2C receptors.

α2-adrenoreceptor antagonist

Iloperidone metabolite P95 is a metabolite of the atypical antipsychotic iloperidone . It binds to the serotonin (5-HT) receptor subtype 5-HT2A and α1-, α2B-, and α2C-adrenergic receptors with mean Ki values of 7.08, 21.38, 83.18, and 47.86 nM, respectively, but does not cross the blood-brain barrier.