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Results for "

r112

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    4
    TargetMol | Inhibitors_Agonists
  • Antibody Products
    6
    TargetMol | Antibody_Products
R112
T3185575474-82-7
R112 is an ATP-competitive inhibitor of Syk kinase. Ki=6 nM,IC50=226 nM.
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DBPR112
T109651226549-49-0In house
DBPR112 is an orally active furanopyrimidine-based EGFR inhibitor with IC50s of 15 nM for EGFRWT and 48 nM for EGFRL858R T790M, capable of occupying the ATP-binding site and demonstrating significant antitumor efficacy.
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6-8 weeks
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SR11237
SR 11237
T23383146670-40-8
SR11237 is a Pan retinoid X receptor (RXR) agonist. SR11237 causes RXR RXR homodimers to form and transactivate a reporter gene containing a RXR-response element.
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6-8 weeks
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DBPR112 HCl
T694982889316-21-4
DBPR112 is a potent EGFR inhibitor (IC50=487 nM) as a Clinical Candidate for the Treatment of Non-Small Cell Lung Cancer. DBPR112), DBPR112 not only displayed a potent inhibitory activity against EGFRL858R T790M double mutations but also exhibited tenfold potency better than the third-generation inhibitor, osimertinib,against EGFR and HER2 exon 20 insertion mutations. Overall, pharmacokinetic improvement through lead-to-candidate optimization yielded fourfold oral AUC better that afatinib along with F = 41.5%, an encouraging safety profile, and significant antitumor efficacy in in vivo xenograft models.
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1-2 weeks
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