r-glutamylcysteine

Gamma-glutamylcysteine TFA (γ-glutamylcysteine TFA) is a precursor of glutathione (GSH) with antioxidant and anti-inflammatory properties. It alleviates oxidative stress and mitochondrial damage induced by ethanol in hepatocytes by increasing cellular GSH, SOD activity, and mitochondrial membrane potential, protecting cells from alcohol-induced liver disease (ALD) by inhibiting oxidative stress, reducing inflammation, and preventing cell apoptosis.

L-Buthionine-(S,R)-sulfoximine, a cell-permeable and irreversible inhibitor of γ-glutamylcysteine synthetase (Ki <100 μM), induces oxidative stress in cells by depleting GSH.

DL-Buthionine-(S,R)-sulfoximine hydrochloride (Buthionine sulfoximine hydrochloride) is a potent and specific inhibitor of glutamylcysteine synthetase biosynthesis.

L-Buthionine-(S,R)-sulfoximine hydrochloride is a potent, cell-permeable, fast-acting, irreversible inhibitor of G-glutamylcysteine synthetase (γ-GCS) that depletes cellular glutathione levels. It has IC50s of 1.9 μM, 8.6 μM, and 29 μM in melanoma, breast, and ovarian tumor specimens, respectively [1] [2].

DL-Buthionine-(S,R)-sulfoximine (Butionine sulfoximine) is an inhibitor of γ-glutamylcysteine synthetase used for the treatment of solid tumors.