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r-850

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  • Inhibitors & Agonists
    2
    TargetMol | Inhibitors_Agonists
R-8507
T38339338773-13-0
R-8507 is a small molecule antagonist of the TNF-α type 1 receptor (TNF-αRI). It inhibits the expression of intercellular adhesion molecule-1 (ICAM-1) induced by TNF-α and IL-1β with EC50 values of 2.45 and 3.79 μM, respectively, in an ELISA using A549 lung epithelial cells.{|Gururaja2007|} It also disrupts the interaction of the TNF-αRI with receptor interacting protein 1 (RIP1) and TNF-αR-associated death domain protein (TRADD), preventing internalization of the receptor complex.
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6-8 weeks
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Sotirimod
S-30594, R850
T16913227318-75-4In house
Sotirimod(R850) is a novel immunomodulator with antitumor and antiviral activity for the study of actinic keratoses.
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6-8 weeks
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