ppt

PPT is a modulator of water-heme interactions of CYP2C9d and CYP125A1 in low-spin P450 complexes.

Propyl pyrazole triol (PPT) is a selective agonist of estrogen receptor alpha (ERα), exhibiting a relative binding affinity of 49% for ERα, which is approximately 410 times higher than its affinity for estrogen receptor beta (ERβ: 0.12%).

(20S)-Protopanaxatriol (g-PPT)(g-PPT), a metabolite of ginsenoside, could regulate endothelial cell functions through the estrogen receptor and glucocorticoid receptor.

PPTN is a high-affinity, competitive and highly selective antagonist of P2Y14 receptor(KB value of 434 pM), with anti-inflammatory and immune activity.

PPTN hydrochloride is a potent, high-affinity, competitive, and highly selective P2Y14 receptor antagonist (KB: 434 pM) with no agonist or antagonist activity at P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, or P2Y13 receptors, exhibiting anti-inflammatory and anti-immune effects.

PPTN Mesylate is an effective and highly selective antagonist of the P2Y14 receptor.

DMA-CPPTL is a prodrug of CPPTL which induces apoptosis in a dose-dependent manner via the ROS/JNK pathway in acute myeloid leukemia.

PptT-IN-1 (compound 5j) is a highly potent inhibitor (IC50: 2.8 μM) of phosphopantetheinyl phosphoryl transferase (PptT), an essential enzyme in the biosynthesis of cellular lipids and virulence factors in Mycobacterium tuberculosis, demonstrating considerable potential for tuberculosis research [1].

PptT-IN-3 (compound 5p) is a powerful inhibitor (IC50 = 3.5 μM) of phosphopantetheinyl phosphoryl transferase (PptT), an indispensable enzyme involved in the synthesis of cellular lipids and virulence factors in Mycobacterium tuberculosis. This compound holds promise for tuberculosis research [1].

PptT-IN-2 (compound 5k) is a highly effective inhibitor of phosphopantetheinyl phosphoryl transferase (PptT), with an IC50 of 2.5 μM. PptT is an indispensable enzyme crucial for synthesizing cellular lipids and virulence factors in Mycobacterium tuberculosis. Therefore, PptT-IN-2 holds great promise for further investigations into tuberculosis research [1].

PptT-IN-4 (Compound 3a) is a PptT inhibitor with an IC50 of 0.71 μM, demonstrating antimycobacterial activity against Mtb H37Rv with a MIC of 42 μM. It inhibits hERG, hCav1.2, and hNav1.5 channels with IC50 values of 11 μM, 8.1 μM, and 6.9 μM, respectively [1].

ppTG20 is an amphiphilic cell-penetrating peptide (KALA) utilized for gene transfection. It has the ability to bind with DNA, disrupt membrane stability, and mediate DNA transfection.

VPSTPPTPSPSTPPTPSPS is a type of IgA1 hinge peptide.

VPSTPPTPSPSTPPTPSPS (TFA) is a peptide from the IgA1 hinge region.

C15AlkOPP Tetrabutylamine salt is a "clickable" alkyne-modified analogs of the lipid substrates farnesyl diphosphate (FPP).

C15AlkOPP Tetrabutylamine salt (1:2) is an FPP analogue, bearing an alkyne group to allow for post-prenylation protein labeling. C15AlkOPP Tetrabutylamine salt (1:2) can be used for Prenylomic analysis

HMBPP triammonium is a stimulator of gamma delta T cells.

Rapastinel (TPPT-amide) (GLYX-13) is an N-methyl-D-aspartate receptor (NMDAR) modulator.

Geranylgeranyl Pyrophosphate triammonium (GGPP triammonium) is a metabolite involved in protein geranylgeranylation, modulating endothelial cell proliferation and apoptosis during mouse embryonic angiogenesis. GGPP triammonium amplifies T(reg) differentiation by increasing IL-2 expression, improving DSS-induced colitis, useful in cancer research.

DMAPP triammonium (Dimethylallyl diphosphate triammonium) is one of the prerequisite substances for an isoprenoid involved in the mevalonate (MVA) pathway, which can be used in the study of metabolism-related diseases.

DC661 is a palmitoyl-protein thioesterase 1 (PPT1) inhibitor that acts as an anti-lysosomal agent by inhibiting autophagy, demonstrating anti-cancer activity.

ML267 (4-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(4-methoxypyridin-2-yl)piperazine-1-carbothioamide trifluoroacetate) is a potent inhibitor of bacterial phosphopantetheinyl transferase that attenuates secondary metabolism and thwarts bacterial growth[1].

LQVTDSGLYRCVIYHPP (LP17) TFA is a TREM-1 (triggering receptor expressed on myeloid cells) inhibitory peptide that significantly reduces ischemic infarction and neuronal damage, with the ability to penetrate the brain to inhibit TREM-1 [1].

LPP Tripeptide, a blood pressure-lowering tripeptide, is utilized in hypertension research [1].