polyketide synthase 13-in-1

Polyketide synthase 13-IN-1 (compound 32) is an inhibitor of polyketide synthase 13.

Pks13-IN-1 (Compound 44) is an orally active inhibitor of Mycobacterium tuberculosis polyketide synthase 13 (Pks13). It inhibits the M. tuberculosis H37Rv strain with a minimum inhibitory concentration (MIC) of 0.07 μM. In mouse models, Pks13-IN-1 demonstrates antibacterial activity.

Polyketide synthase 13-IN-2 (comp 42) is a potent inhibitor of polyketide synthase 13 in Mycobacterium tuberculosis, demonstrating a minimum inhibitory concentration (MIC) of 0.25 μg mL [1].

Thiophene-2 (TP2) is a targeted inhibitor of polyketide synthase 13 (Pks13), specifically designed to disrupt mycolic acid biosynthesis, effectively inducing rapid cell death in mycobacteria. It demonstrates notable anti-tuberculosis activity and exhibits a minimum inhibitory concentration (MIC) value of 1 μM against Mycobacterium tuberculosis.