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Results for "
pipinib
" in TargetMol Product Catalog.- Inhibitors & Agonists1
- PipinibT2175672380013-55-6Pipinib is an ATP-competitive and selective phosphatidylinositol 4-kinase IIIβ (PI4KB) inhibitor with an IC50 value of 2.2 μM. Pipinib reduces intracellular PI4P levels and inhibits GLI-mediated transcription as well as the expression of Hedgehog target genes. Pipinib additionally blocks the trafficking of Smoothened to primary cilia. Pipinib is applicable to investigations involving basal cell carcinoma, medulloblastoma, Hedgehog signaling, and phosphoinositide-associated cellular regulation.Inquiry
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