phosphate binder

Sevelamer carbonate is a non-absorbed phosphate binding crosslinked polymer, with the same polymeric structure as sevelamer hydrochloride, in which carbonate replaces chloride as the counterion.

TMX-4102 is a highly selective binder of phosphatidylinositol 5-phosphate 4-kinase Type II gamma (PIP4K2C). It demonstrates binding activity to PIP4K2C with a dissociation constant (KD) of 0.45 nM, and does not significantly affect other lipid and non-lipid kinases. By specifically binding to PIP4K2C, TMX-4102 regulates its scaffold function rather than its enzymatic activity. TMX-4102 serves as a tool molecule for studying the biological functions and potential therapeutic value of PIP4K2C.

Bixalomer is a phosphate binder that alleviates hyperphosphatemia in rat models of chronic kidney disease (CKD). By binding phosphate in the small intestine, Bixalomer reduces phosphate absorption, thereby decreasing plasma phosphate levels in CKD rat models. It is applicable for research related to hyperphosphatemia.

Colestilan (MCI-196), a non-absorbable, non-calcium-based phosphate binder and anion exchange resin, exhibits oral activity and is utilized in the study of hypercholesterolemia [1] [2].

Calcium acetate, United States Pharmacopeia (USP) Reference Standard [Calcium acetate (Pharmaceutical primary standard, USP)], is a phosphate binder that reduces phosphate levels and meets USP standards.

Ferric citrate hydrate is an orally active iron supplement and an effective phosphate binder. It is used in research on iron deficiency anemia and chronic kidney disease (CKD).