pg01

PG01 is a potent CFTR Cl-channel potentiator, effective against ΔF508 (Ka 0.3 μM), and also against E193K, G970R and G551D (CFTR mutants), with Kd values of 0.22 μM, 0.45 μM and 1.94 μM, respectively.PG01 increases ΔF508-CFTR Cl- currents upon addition of forskolin. F508-CFTR Cl-current upon addition of Forskolin, correcting the gating defect of CFTR mutants.

GLPG0187, a broad spectrum integrin receptor antagonist, inhibits αvβ1-integrin (IC50: 1.3 nM).

RPG-01-132 is a targeted degrader (PORTAC) of the dengue virus capsid protein (DENV capsid protein), with a DC50 of 2.4 μM. It inhibits viral assembly, clears viral particles, and disrupts the non-structural functions of the capsid protein. RPG-01-132 exhibits significant antiviral activity against all four DENV serotypes, as well as ST148-resistant DENV2 mutants, making it a valuable compound for research related to dengue virus infections.

PG 01037 dihydrochloride (PG-01037 2HCl) is a potent and selective dopamine D3 receptor antagonist with a Ki of 0.7 nM.