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pfi-3

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  • Inhibitors & Agonists
    4
    TargetMol | Inhibitors_Agonists
PFI-3
PFI 3
T69391819363-80-8
PFI-3 is a selective chemical inhibitor for SMARCA (2 4) (Kd = 89 nM)and PBI (5) bromodomains which may result in the delay and prevention of breast cancer.
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Bromodomain inhibitor-13
T2000621914047-59-8
Bromodomain Inhibitor-13 (Compound 1), an analog of PFI-3, is a bromodomain-containing protein (BCP) inhibitor. It specifically targets the bromodomains of SMARCA2, SMARCA4, and the first and second bromodomains of PB1 [PB1(5) and PB1(2)], with dissociation constants (KD) of 37, 53, 30, and 190 nM, respectively.
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10-14 weeks
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BRG1-IN-1
T608702616813-99-9
BRG1-IN-1 (Compound 11d) is a potent BRG1 inhibitor that surpasses PFI-3 in sensitizing GBM cells to the antiproliferative and cell death-inducing effects of Temozolomide in vitro, and enhances Temozolomide's inhibitory effect on subcutaneous GBM tumor growth[1].
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6-8 weeks
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PFI-6
T871352675452-91-0
PFI-6 is a selective and non-cytotoxic probe targeting the YEATS domain of MLLT1 (ENL YEATS1) and MLLT3 (AF9 YEATS3), with IC50 values of 140 nM for MLLT1 and 160 nM for MLLT3. It serves as a molecular tool to investigate the role of MLLT1 3 in diseases and genome validation studies [1].
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10-14 weeks
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