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By Target- Apoptosis
- EGFR(1)
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Results for "
pf-299
" in TargetMol Product Catalog- Inhibitors & Agonists1
Dacomitinib
PF-299804, PF-00299804, PF299
T24831110813-31-4
Dacomitinib (PF299)(PF299804; PF-00299804) is a highly selective, orally bioavailable small-molecule inhibitor of the HER family of tyrosine kinases with IC50 of 6, 45.7 and 73.7 nM for EGFR, ERBB2, and ERBB4, respectively.
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PF-299804, PF299804, PF-00299804, PF00299804, PF 299804, PF 00299804
T199651042385-75-0
Dacomitinib hydrate (PF 299804) is a highly selective and second-generation small-molecule inhibitor of the pan-epidermal growth factor receptor family of tyrosine kinases. Dacomitinib specifically and irreversibly binds to and inhibits human EGFR subtypes, resulting in inhibition of proliferation and induction of apoptosis in EGFR-expressing tumor cells.
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