pbr322 dna

SJG-136 is a DNA cross-linking agent with an XL50 value of 45 nM for pBR322 DNA. SJG-136 demonstrates potent antitumor activity and is applicable to investigations involving DNA cross-link formation, genomic damage responses, and tumor-associated cellular stress pathways.

1-Cinnamoylpyrrolidine, a natural product prepared from Piper caninum, can be used as a DNA strand breaking agent, inducing the relaxation of the plasmid pBR322 DNA superhelix in the presence of Cu2+. 1-Cinnamoylpyrrolidine inhibits PAF-induced platelet aggregation with an IC50 value of 37.3 μM. value was 37.3 μM.

Vincosamide is an alkaloid from Psychotria leiocarpa extract, inhibits the acetylcholinesterase (AChE) activity with anti-inflammatory activity. Vincosamide can effect relaxation of the supercoiled pBR322 plasmid DNA in the presence of Cu2+.