pbp4

PBP4-IN-1 (Compound 1) is an inhibitor targeting penicillin-binding protein 4 (PBP4) in Staphylococcus aureus. By inhibiting the function of PBP4, PBP4-IN-1 enhances the antibiotic activity against methicillin-resistant Staphylococcus aureus (MRSA) mediated by PBP2a. This compound is used in studies involving osteomyelitis caused by Staphylococcus aureus and in research aimed at reversing PBP4-mediated resistance to β-lactam antibiotics.

Cefoxitin (Rephoxitin) is a broad-spectrum, orally available second-generation cephalosporins antibiotic. Cefoxitin interferes with the synthesis of bacterial cell walls. Its activity profile includes Gram-negative and Gram-positive bacteria, and is commonly used in abdominal cavity infections, pelvic infections, and certain types of gynecological infections, and is highly effective against anaerobic bacteria.