p-401

Hexamide is a protein inhibitor.

CEP-40125 (RXDX-107) is a DNA alkylating agent used for researching advanced solid tumors.

P-4010 is effective against herpes simplex.

FMP-401319-3 is a concentration-dependent inhibitor of CRF1R-pPL cotranslational translocation at the level of the Sec61 complex.

Laromustine (VNP40101M) is a sulfonyl hydrolytic alkylating prodrug used in cancer therapy with significant anticancer activity. Inhibiting thioredoxin reductase can be used to study acute myeloid leukemia.

9-(Boc-amino)nonanoic Acid is an alkane chain with terminal carboxlic acid and Boc-protected amino groups. The compound can be used as a PROTAC linker in the synthesis of PROTACs. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.

MG1 peptide is a targeting peptide for M1 microglial cells. It can be conjugated with nanoparticles to traverse the blood-brain barrier, accurately identify M1 microglial cells, and enable controlled drug release and specific accumulation through an intelligent molecular switch. MG1 peptide is applicable in drug delivery research for ischemic stroke.

NN1213 acetate (Peptide 21) is a long-acting human amylin peptide analog, functioning as a selective amylin receptor agonist with EC50 values of 0.177 nM for hAMY3R and 0.262 nM for rAMY3R. In rat and dog models, NN1213 acetate significantly reduces appetite and is applicable for anti-obesity research.

LAGIPRA peptide TFA is a long-acting GIP1R agonist. It improves insulin sensitivity by enhancing glucose processing and reducing circulating branched-chain amino acids (BCAA) and keto acids. LAGIPRA peptide TFA shows potential for research in type 2 diabetes.

Ribupatide TFA is a dual agonist of the gastric inhibitory polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptors. It finds application in diabetes research.

c-RGD-SH is a ligand for integrin αvβ3 (Integrin αvβ3). By conjugating c-RGD-SH with core-crosslinked polymeric micelles (CCPM), it is possible to synthesize bimodal nanoparticle probes. These probes, when labeled with Cy7 and 111In, can be employed for tumor imaging using SPECT and NIRF techniques.

SFTI-KLK5 is a KLL5 inhibitor with a Ki value of 5.1 nM.

NHIP peptide is a 20-amino acid segment located within the cell nucleus. It is highly expressed in neuron-derived cells such as LUHMES cells. Additionally, NHIP peptide promotes the proliferation of 293T cells and regulates gene networks associated with neurodevelopment and autism spectrum disorders (ASD).

The compound GYGGGP(GPP)5GFOGER(GPP)5GPC TFA is a type I collagen mimic that can bind to integrins and be used to modify hydrogels.

Cys-PKHB1 (Cys-txCD47) TFA is a polypeptide consisting of a cysteine (Cys) residue conjugated with PKHB1, which is a CD47 agonist peptide that mimics the anti-tumor effects of thrombospondin-1 peptides. In breast cancer cells, PKHB1 induces mitochondrial changes, ROS production, intracellular accumulation of Ca+, and calcium-dependent cell death. Furthermore, PKHB1 activates the immune system through immunogenic cell death of breast cancer cells.

Bz-Pro-Phe-Arg-pNA (Bz-PFR-pNA) hydrochloride is a chromogenic peptide substrate for plasma and glandular kallikrein, cysteine protease (cruzipain), and trypsin. It can be used for the determination of Factor XII.