oridonin

Oridonin (NSC-250682) is a diterpenoid isolated from Rabdosia rubescens with anti-tumor, anti-bacterial and anti-inflammatory effects. It acts as an inhibitor of AKT, with IC50s of 8.4 and 8.9 μM for AKT1 and AKT2.

Oridonin (Standard) is a reference standard for research and analysis in studies involving Oridonin. Oridonin (NSC-250682) is a diterpenoid isolated from Rabdosia rubescens with anti-tumor, anti-bacterial and anti-inflammatory effects. It acts as an inhibitor of AKT, with IC50s of 8.4 and 8.9 μM for AKT1 and AKT2.

CYD0682 is an analog of Oridonin. It reduces the activation of STAT3 and the production of ECM in hepatic stellate cells via the HSP90 pathway.

Anticancer agent 28 showed good anti-tumour effects in vivo in H22 allograft mice. anticancer agent 28 was 50 times more potent than Oridonin against K562 cells with an IC50 value of 0.09 μM.

Anticancer Agent 39 (compound B12), a fluorescent derivative of Jiyuan Oridonin A (JOA), not only induces apoptosis through the collapse of mitochondrial membrane potential (MMP) but also inhibits cell cloning and migration, demonstrating promising anti-proliferative activity against HGC-27 cells with an IC50 value of 0.39 μM [1].

Desthiobiotin-Iodoacetamide is a functionalised reagent formed by linking desthiobiotin and iodoacetamide (IAM). It serves as a probe for investigating cysteine reactivity and may also function as an ADC Linker.