nsc-268508

Spermine (Neuridine) is an endogenous polyamine in the human body. As a direct free radical scavenger, it exhibits antiviral activity and protects DNA from free radical damage; it is also a key regulator of cell proliferation, differentiation, and apoptosis. Spermine inhibits certain bacteria, particularly strains of Staphylococcus aureus. Spermine induces striatal neurotoxicity in a dose-dependent manner. Spermine reversibly inhibits DNA synthesis, mixed lymphocyte reactions, and the induction of cytolytic lymphocyte reactions in primary cultures of mouse splenocytes.

Spermine (Standard) is the reference standard of spermine, suitable for quantitative analysis, quality control, biochemical experiments, and related research. Spermine (neuridine) acts as a direct free radical scavenger with antiviral effects and protects DNA from free radical attack.

Spermine-15N2 (NSC 268508-15N2) is the 15N-labeled version of Spermine. This compound acts as a natural antioxidant and anti-inflammatory agent. Spermine is effective in inhibiting certain bacterial cultures, particularly strains of Staphylococcus aureus, and induces dose-dependent neurotoxicity in the striatum. It can reversibly inhibit DNA synthesis reactions, mixed lymphocyte reactions, and cytotoxic lymphocyte responses in primary cultures of mouse splenocytes. As a polyamine nitric oxide donor, Spermine tetrahydrochloride supplies nitric oxide to platelets and inhibits platelet activation in a concentration-dependent manner. This compound is present in mammalian tissues, plants, bacteria, ribosomes, and bacteriophages, and it can inhibit primary human embryonic lung fibroblast cells in vitro.