nsc-125973

Paclitaxel (Taxol) is a natural product and a microtubule polymer stabilizer. Paclitaxel has anti-tumor activity and causes cell death by inducing mitotic arrest, apoptosis, and cell autophagy.

Paclitaxel Ceribate is a mitotic inhibitor used in cancer chemotherapy.

DHA-paclitaxel, also know as Taxoprexin, is prodrug comprised of the naturally occurring omega-3 fatty acid docosahexaenoic acid (DHA) covalently conjugated to the anti-microtubule agent paclitaxel. Because tumor cells take up DHA, DHA-paclitaxel is delivered directly to tumor tissue, where the paclitaxel moiety binds to tubulin and inhibits the disassembly of microtubules, thereby resulting in the inhibition of cell division. Paclitaxel also induces apoptosis by binding to and blocking the function of the apoptosis inhibitor protein Bcl-2 (B-cell Leukemia 2). DHA-paclitaxel exhibits improved pharmacokinetic and toxicity profiles when compared to conventional paclitaxel and has demonstrated antineoplastic activity in animal models of cancer.

Paclitaxel-d5 is the deuterated analog of Paclitaxel, a diterpenoid natural product originally isolated from Pacific yew bark. Paclitaxel-d5 maintains the parent compound’s ability to stabilize microtubules and induce mitotic arrest leading to apoptosis, and it is widely used as an internal standard in analytical assays and mechanistic drug studies.