non-carbohydrate

M-31850 (1H-Benz[de]isoquinoline-1,3(2H)-dione, 2,2'-(iminodi-2,1-ethanediyl)bis-) is a potent, selective and competitive β-hexosaminidase (Hex) inhibitor(human HexA and human HexB with IC50s of 6.0 μM and 3.1 μM, respectively). IT also competitively inhibits β-N-acetyl-D-hexosaminidase OfHex2 with a Ki of 2.5 μM.

D-mannoheptose is the main non-structural carbohydrate in avocado. D-mannoheptose is a specific inhibitor of D-glucose phosphorylation. D-mannoheptose can prevent the release of insulin and the utilization of carbohydrates in rats.

Aspartame (SC-18862), an artificial, non-carbohydrate sweetener, is aspartyl-phenylalanine-1-methyl ester.

4"-C18 EGCG is an effective inhibitor of α-amylase and α-glucosidase, with IC50 values of 3.74 μM and 0.81 μM respectively. It inhibits carbohydrate-hydrolyzing enzymes, reducing oxidative stress and inflammation, and demonstrates anti-diabetic activity. Additionally, 4"-C18 EGCG downregulates pro-inflammatory cytokines and exhibits cytotoxicity at 50 μM in primary human peripheral blood mononuclear cells (PBMC), and non-cancerous cell lines 3T3-L1 and HEK 293.

4''-C18 EGCG is an effective inhibitor of α-amylase and α-glucosidase, with IC50 values of 3.74 and 0.81 μM, respectively. This compound suppresses carbohydrate-hydrolyzing enzymes, reduces oxidative stress and inflammation, and exhibits anti-diabetic activity. Moreover, 4''-C18 EGCG downregulates pro-inflammatory cytokines and demonstrates cytotoxicity at 50 μM against primary human peripheral blood mononuclear cells (PBMC), as well as non-cancerous cell lines 3T3-L1 and HEK 293.

α-Glucosidase-IN-92 (compound 14b) is a non-competitive inhibitor targeting α-glucosidase with an IC50 of 64.0 μM, displaying greater inhibitory potency than Acarbose (IC50=750 μM). It has excellent oral bioavailability and can cross the blood-brain barrier. This compound slows carbohydrate hydrolysis and reduces postprandial blood glucose levels, making it useful for antidiabetic studies in type 2 diabetes.

α-Glucosidase (α-D-Glucosidase) is a carbohydrate hydrolyzing enzyme that catalyzes the release of α-glucose from the non-reducing end of the substrate, playing a vital role in glucose absorption by the small intestine. Inhibiting α-Glucosidase effectively manages non-insulin-dependent diabetes mellitus (NIDDM).

Aspartame (Standard) is the standard substance of Aspartame, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Aspartame (SC-18862), an artificial, non-carbohydrate sweetener, is aspartyl-phenylalanine-1-methyl ester.

α-Glucosidase, bacillus stearothermophilus, is a carbohydrate enzyme that facilitates the release of α-glucose molecules. It retains exoglycosidase activity, enabling the hydrolysis of α-glycosidic bonds at the non-reducing ends of substrates.

α-Glucosidase, rice is a carbohydrate enzyme that facilitates the release of α-glucose molecules. It functions as an exoglycosidase, hydrolyzing α-glycosidic bonds at the non-reducing end of substrates.

4-Amino-2,6-anhydro-3,4-dideoxy-D-glycero-D-galacto-non-2-enoic acid is a biochemical reagent utilized in glycomics research. This field examines the structure, synthesis, biology, and evolution of sugars, encompassing carbohydrate chemistry, glycan synthesis and degradation enzymology, protein-glycan interactions, as well as the role of glycans in biological systems. It is closely linked to fundamental research, biomedicine, and biotechnology.

Carbohydrate Sulfotransferase 2 (EC:2.8.2.-) catalyzes the transfer of sulfate groups to the C-6 position of non-reducing GlcNAc residues within keratan-like structures on N-glycans and mucin-associated glycans.

Carbohydrate Sulfotransferase 4 (EC:2.8.2.-) catalyzes the transfer of sulfate groups to the hydroxyl group at the C-6 position of the non-reducing GlcNAc residues within O-linked mucin-type glycans.

Carbohydrate Sulfotransferase 5 (EC:2.8.2.-) catalyzes the transfer of sulfate groups to non-GlcNAc residues of mucin-type receptors and the 6-position of O-linked sugars.

Carbohydrate Sulfotransferase 6 (EC:2.8.2.21) catalyzes the transfer of sulfates to the 6-position of a non-reducing GlcNAc residue in keratan.

Carbohydrate Sulfotransferase 7 (EC:2.8.2.17) catalyzes the transfer of sulfate groups to the 6th position of non-GlcNAc residues as well as to the 6th position of chondroitin GalNAc residues.