non-carbohydrate

M-31850 (1H-Benz[de]isoquinoline-1,3(2H)-dione, 2,2'-(iminodi-2,1-ethanediyl)bis-) is a potent, selective and competitive β-hexosaminidase (Hex) inhibitor(human HexA and human HexB with IC50s of 6.0 μM and 3.1 μM, respectively). IT also competitively inhibits β-N-acetyl-D-hexosaminidase OfHex2 with a Ki of 2.5 μM.

D-mannoheptose is the main non-structural carbohydrate in avocado. D-mannoheptose is a specific inhibitor of D-glucose phosphorylation. D-mannoheptose can prevent the release of insulin and the utilization of carbohydrates in rats.

Aspartame (SC-18862), an artificial, non-carbohydrate sweetener, is aspartyl-phenylalanine-1-methyl ester.

Volemitol is a natural heptitol with important physiological functions. It is the major non-structural carbohydrate in leaves at various developmental stages, acting as a photosynthetic product for phloem transport and a storage carbohydrate. Its biosynthesis is catalyzed by a novel NADPH-dependent ketose reductase.

4''-C18 EGCG is an effective inhibitor of α-amylase and α-glucosidase, with IC50 values of 3.74 and 0.81 μM, respectively. This compound suppresses carbohydrate-hydrolyzing enzymes, reduces oxidative stress and inflammation, and exhibits anti-diabetic activity. Moreover, 4''-C18 EGCG downregulates pro-inflammatory cytokines and demonstrates cytotoxicity at 50 μM against primary human peripheral blood mononuclear cells (PBMC), as well as non-cancerous cell lines 3T3-L1 and HEK 293.

α-Glucosidase-IN-92 (compound 14b) is a non-competitive inhibitor targeting α-glucosidase with an IC50 of 64.0 μM, displaying greater inhibitory potency than Acarbose (IC50=750 μM). It has excellent oral bioavailability and can cross the blood-brain barrier. This compound slows carbohydrate hydrolysis and reduces postprandial blood glucose levels, making it useful for antidiabetic studies in type 2 diabetes.

SCR005 is a synthetic carbohydrate receptor (SCR) with broad-spectrum antiviral activity. It inhibits the entry of enveloped viruses from several families, including Coronaviridae (SARS-CoV-1, SARS-CoV-2, MERS-CoV), Filoviridae (EBOV, MARV), and Paramyxoviridae (NiV, HeV), as well as the glycosylated non-enveloped rotavirus. SCR005 binds to viral envelope N-glycans, blocking the virus from attaching to host cells or disrupting both attachment and membrane fusion. It demonstrates a preventive effect in hACE2 mice infected with SARS-CoV-2. SCR005 is applicable for the study and prevention of enveloped viral pandemics.

SCR007 is a synthetic carbohydrate receptor (SCR) known for its broad-spectrum antiviral activity. It inhibits the entry of enveloped viruses across several families, including coronaviruses (SARS-CoV-1, SARS-CoV-2, MERS-CoV), filoviruses (EBOV, MARV), and paramyxoviruses (NiV, HeV), as well as glycosylated non-enveloped rotaviruses. SCR007 targets the N-glycans on virus envelopes, blocking viral attachment to host cells or hindering both attachment and membrane fusion. It exhibits preventive effects in hACE2 mice infected with SARS-CoV-2 and can be employed for research and prevention of pandemics caused by enveloped viruses.

α-Glucosidase (α-D-Glucosidase) is a carbohydrate hydrolyzing enzyme that catalyzes the release of α-glucose from the non-reducing end of the substrate, playing a vital role in glucose absorption by the small intestine. Inhibiting α-Glucosidase effectively manages non-insulin-dependent diabetes mellitus (NIDDM).

AP-III-a4 (ENOblock) is the first non-substrate analogue that directly binds to enolase to inhibit its catalytic activity with an IC50 of 0.576 μM, thereby blocking cancer cell metastasis in vivo. AP-III-a4 can be used in research on tumor metabolism, metastasis, and diseases related to carbohydrate metabolism.

Chinese gallotannin, derived from Galla Chinensis, is a non-specific promiscuous inhibitor of various enzymes. It is a potent inhibitor of human salivary α-amylase, with a Ki value of 0.82 μg/mL. Mechanistic studies reveal that gallotannins exert their inhibitory effects through the formation of aggregates, which serve as the active species in the inhibition process. Beyond its role in carbohydrate metabolism, it exhibits inhibitory activity against telomerase, fatty acid synthase, and 5α-reductase, making it a versatile tool for research in diabetes, oncology, and metabolic disorders.

L-Alanine-1-13C,15N is an isotopically labeled version of L-Alanine, marked with both 13C and 15N. L-Alanine (TJO2729) is a non-essential amino acid involved in carbohydrate and acid metabolism, enhancing immune function, and supplying energy to muscle tissue, the brain, and the central nervous system.

L-Alanine-13C2,15N is an isotopically labeled form of L-Alanine, marked with 13C and 15N. L-Alanine (TJO2729) is a non-essential amino acid involved in carbohydrate and acid metabolism, boosts the immune system, and provides energy to muscle tissues, the brain, and the central nervous system.

Aspartame (Standard) is the standard substance of Aspartame, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Aspartame (SC-18862), an artificial, non-carbohydrate sweetener, is aspartyl-phenylalanine-1-methyl ester.

α-Glucosidase, bacillus stearothermophilus, is a carbohydrate enzyme that facilitates the release of α-glucose molecules. It retains exoglycosidase activity, enabling the hydrolysis of α-glycosidic bonds at the non-reducing ends of substrates.

α-Glucosidase, rice is a carbohydrate enzyme that facilitates the release of α-glucose molecules. It functions as an exoglycosidase, hydrolyzing α-glycosidic bonds at the non-reducing end of substrates.

4-Amino-2,6-anhydro-3,4-dideoxy-D-glycero-D-galacto-non-2-enoic acid is a biochemical reagent utilized in glycomics research. This field examines the structure, synthesis, biology, and evolution of sugars, encompassing carbohydrate chemistry, glycan synthesis and degradation enzymology, protein-glycan interactions, as well as the role of glycans in biological systems. It is closely linked to fundamental research, biomedicine, and biotechnology.

Carbohydrate Sulfotransferase 2 (EC:2.8.2.-) catalyzes the transfer of sulfate groups to the C-6 position of non-reducing GlcNAc residues within keratan-like structures on N-glycans and mucin-associated glycans.

Carbohydrate Sulfotransferase 4 (EC:2.8.2.-) catalyzes the transfer of sulfate groups to the hydroxyl group at the C-6 position of the non-reducing GlcNAc residues within O-linked mucin-type glycans.

Carbohydrate Sulfotransferase 5 (EC:2.8.2.-) catalyzes the transfer of sulfate groups to non-GlcNAc residues of mucin-type receptors and the 6-position of O-linked sugars.

Carbohydrate Sulfotransferase 6 (EC:2.8.2.21) catalyzes the transfer of sulfates to the 6-position of a non-reducing GlcNAc residue in keratan.

Carbohydrate Sulfotransferase 7 (EC:2.8.2.17) catalyzes the transfer of sulfate groups to the 6th position of non-GlcNAc residues as well as to the 6th position of chondroitin GalNAc residues.