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(1)
By Target- ADC Cytotoxin
- Autophagy(1)
- DNA/RNA Synthesis(1)
- Topoisomerase(1)
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Results for "
nk-012
" in TargetMol Product Catalog- Inhibitors & Agonists1
SN-38
SN 38, NK012
T170386639-52-3
SN-38 (NK012) is the active metabolite of Irinotecan, a DNA topoisomerase I (Topo I) inhibitor, which inhibits DNA and RNA synthesis (IC50=0.077 1.3 μM). SN-38 has antitumor activity and induces autophagy.
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T89645718612-49-8
SN-38-d3 is a deuterated form of SN-38. As the active metabolite of the topoisomerase I (TopoisomeraseI) inhibitor irinotecan, SN-38 (NK012) notably inhibits the synthesis of DNA and RNA, with IC50 values of 0.077 and 1.3 μM, respectively.
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T73905121080-63-5
SN-38 glucuronide, an inactive metabolite of Irinotecan, serves as a derivative of this cancer-fighting agent. Irinotecan, known for inhibiting topoisomerase I, is utilized in the research of colon and rectal cancer [1].
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