nitd 2

NITD-2 is a dengue virus (DENV) polymerase inhibitor, inhibits the DENV RdRp-mediated RNA elongation. NITD-2 penetrates cell membrane poorly. Dengue virus (DENV) is the most prevalent mosquito- borne viral pathogen in humans. Neither vaccine nor antiviral therapy is currently available for DENV.

HN-11501 is a Thromboxane A2 receptor antagonist.

NITD-203 is a flavivirus inhibitor.

NITD-916, a 4-hydroxy-2-pyridone derivative, is a mycobacterial enoyl reductase InhA inhibitor (IC50=570 nM) with oral activity and high lipophilicity. Capable of forming a ternary complex with InhA and NADH, blocking fatty acyl substrate binding and inhibiting mycolic acid synthesis, thereby exerting potent anti-tuberculosis effects.

NITD008 (7-Deaza-2'-C-acetylene-adenosine) is a potent and selective adenosine nucleoside inhibitor.NITD008 is an adenosine nucleoside analog with broad-spectrum antiviral activity that inhibits dengue, animal cupripoxvirus, and Zika virus.