nh2-peg7

NH2-PEG7 is a para-aminomethylbenzyloxycarbonyl (PROTAC) linker compound consisting of a polyethylene glycol (PEG) chain. It finds application in the synthesis of the PROTAC PARP1 degrader called iRucaparib-AP6[1].

NH2-PEG7-C-COOH is a PROTAC linker utilized in the synthesis of PROTAC molecules.

Boc-NH-PEG7-NH2 is a PEG-based PROTAC linker.

(R)-TCO4-PEG7-NH2 is a PROTAC linker classified under the PEG category. It includes a TCO group, which can undergo a specific "click" reaction with a tetrazine group.

Pomalidomide-PEG7-NH2 hydrochloride is an E3 ubiquitin ligase cereblon (CRBN) ligand based on Pomalidomide, designed for recruiting cereblon proteins. This compound can be linked to a protein ligand via a linker to form a PROTAC.

Thalidomide-5-PEG7-NH2 hydrochloride is a Thalidomide-based cereblon ligand used for CRBN protein recruitment, and it can be conjugated to a protein ligand with a linker to create PROTACs [1].

BCN-endo-PEG7-NH2 is an ADC Linker with 7 PEG units and features the lyophilic bidentate macrocyclic ligand endo-BCN, which is utilized in the synthesis of macrocyclic complexes. In click chemistry, endo-BCN reacts with azide-containing molecules to form stable triazoles without the need for catalysts.

(S)-TCO-PEG7-NH2, an ADC linker featuring seven PEG units, leverages its TCO group to facilitate the inverse electron demand Diels-Alder reaction (iEDDA) with Tetrazine-grouped molecules.