nf κb control

SN50M (NF-κB Control) is a synthetic peptide containing a hydrophobic region and a mutant nuclear localization sequence that enters cells but does not inhibit NF-κB nuclear translocation or induce apoptosis.

Tomatidine hydrochloride (Tomatidine HCl) is a steriodal alkaloid structurally similar to Cyclopamine but does not inhibit hedgehog pathway. May be used as a negative control for Cyclopamine and KAAD-Cyclopamine. Tomatidine protects against muscle atrophy and boosting muscle growth.

MG-1131 is a human monoclonal antibody (mAb) targeting TIGIT. It activates NF-κB signaling in T cells and enhances NK cell-mediated tumor-killing activity in a PVR-dependent manner. By blocking TIGIT, MG-1131 increases IFN-γ secretion. This compound is applicable for research in antitumor immunity. Recommended isotype control: HumanIgG1kappa, Isotype Control.

4-Octylphenol (Standard) is the standard substance of 4-Octylphenol, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. 4-Octylphenol is an endocrine disruptor with gender-specific effects on male germ cells, significantly reducing the mitotic index and the number of spermatogonia. It also causes inflammatory damage in the gills of carp by activating the complement system through the C3a/C3a receptor (C3a/C3aR) axis and C5a/C5a receptor 1 (C5a/C5aR1) axis. Furthermore, 4-Octylphenol induces immune suppression by disrupting the balance between helper T (Th) cells 1/Th2 and regulatory T (Treg)/Th17 cells, and triggers inflammatory damage through the Toll-like receptor 7 (Toll-like Receptor (TLR))/inhibitor κBα/nuclear factor κB (TLR7/IκBα/NF-κB) pathway.

5-Aminosalicylic acid (Standard) is the standard substance of 5-Aminosalicylic acid, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. 5-Aminosalicylic Acid (5-ASA) is a specific PPARγ agonist and also inhibits P21-activated kinase 1(PAK1) and NF-Κb. 5-Aminosalicylic Acid has anti-cancer and anti-inflammatory activities. 5-Aminosalicylic acid can inhibit the activity of osteopontin (OPN).

Aniline-d5 (Standard) is the standard substance of Aniline-d5, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Aniline-d5 is a deuterated isotope marker of Aniline, which can be used for isotope tracing.Aniline induces toxicity to the spleen through iron overload and oxidative stress via heme oxygenase 1 up-regulation and is able to lead to a significant increase in p-IKKα and p-IKKβ, which in turn increases NF-κB and AP-1 binding activity.

Aspirin (Standard) is the standard substance of Aspirin, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Aspirin is an orally active, selective, and irreversible inhibitor of COX-1 and COX-2 with IC₅₀ values of 5 and 210 μg/mL, respectively. It induces apoptosis, inhibits NF-κB activation and platelet prostaglandin synthesis, thereby preventing thrombosis. Additionally, it acts as a histone deacetylase inhibitor that upregulates p21, exhibiting anti-inflammatory, antipyretic, analgesic, and anti-platelet aggregation activities. Aspirin is commonly used to induce gastric ulcer models.

D-Ribose(mixture of isomers) (Standard) is the standard substance of D-Ribose(mixture of isomers), and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. D-Ribose(mixture of isomers) (D-(-)-Ribose), commonly referred to as simply ribose, is a five-carbon sugar found in all living cells. Ribose is not an essential nutrient because it can be synthesized by almost every tissue in the body from other substances, such as glucose. It is vital for life as a component of DNA, RNA, ATP, ADP, and AMP.

Fumaric acid (Standard) is the standard substance of Fumaric acid, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Fumaric acid (2-Butenedioic acid) attenuates the eotaxin-1 expression in TNF-α-stimulated fibroblasts by suppressing p38 MAPK-dependent NF-κB signaling. Fumaric acid has recently been identified as an oncometabolite or an endogenous, cancer-causing metabolite. High levels of this organic acid can be found in tumors or biofluids surrounding tumors. Its oncogenic action appears due to its ability to inhibit prolyl hydroxylase-containing enzymes.

Lidocaine (Standard) is the standard substance of Lidocaine, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Lidocaine (Alphacaine) is an amide local anesthetic with anti-inflammatory properties in vitro and in vivo. It has this functions perhaps due to an attenuation of intracellular adhesion molecule-1 (ICAM-1), pro-inflammatory cytokines, and reduction of neutrophils influx.

Linalool (Standard) is the standard substance of Linalool, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. 1. Linalool (Linalol), a natural compound of the essential oils, has been shown to have antinociceptive, antimicrobial, and anti-inflammatory properties. 2. Linalool was protected against LPS/GalN-induced liver injury through induction of antioxidant defense via Nrf2 activating and reduction inflammatory response via NF-κB inhibition. 3. Linalool biosynthesis and accumulation might be involved in plant defense against bacterial and fungal pathogens and be associated with field resistance to citrus canker. 4. Linalool significantly increased the expression of antioxidant enzymes regulated by Nrf-2 and diminished lung tissue levels of several pro-inflammatory cytokines, including tumor necrosis factor α (TNF-α) and interleukin (IL)-6.

TOMATIDINE HYDROCHLORIDE (Standard) is a reference standard for research and analysis in studies involving TOMATIDINE HYDROCHLORIDE. Tomatidine hydrochloride (Tomatidine HCl) is a steriodal alkaloid structurally similar to Cyclopamine but does not inhibit hedgehog pathway. May be used as a negative control for Cyclopamine and KAAD-Cyclopamine. Tomatidine protects against muscle atrophy and boosting muscle growth.

Methylthiouracil (Standard) is the standard substance of Methylthiouracil, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Methylthiouracil is a thiourea-class antithyroid agent that inhibits the synthesis of thyroid hormones and is commonly used to treat hyperthyroidism. Studies have shown that Methylthiouracil can also suppress the production of TNF-α and IL-6, as well as inhibit the activation of NF-κB and ERK1/2. It can be used to induce hyperlipidemia and neurological disorder models.

Oxaprozin (Standard) is the standard substance of Oxaprozin, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Oxaprozin (Oxaprozinum) is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of oxaprozin is as a Cyclooxygenase Inhibitor. The chemical classification of oxaprozin is Nonsteroidal Anti-inflammatory Compounds.

Quinoclamine (Standard) is the standard substance of Quinoclamine, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Quinoclamine is a naphthoquinone derivative and is an NF-κB inhibitor.

Tyrosol (Standard) is a reference standard of tyrosol. It is suitable for quantitative analysis, quality control, biochemical experiments, and related research. Tyrosol (2-(4-hydroxyphenyl)ethanol) is a derivative of phenethyl alcohol. It reduces pro-inflammatory cytokines from astrocytes, inhibits NF-κB activation, and exerts anti-inflammatory and antioxidant effects.

Engeletin (Standard) is a reference standard of Engeletin intended for quantitative analysis, quality control, and related biochemical research applications.

N,N-Dimethylacetamide (Standard) is a reference standard of N,N-Dimethylacetamide intended for quantitative analysis, quality control, and related biochemical research applications.

D-Ribose(Mixture Of Isomers)-13C5 (Standard) is a reference standard of D-Ribose(Mixture Of Isomers)-13C5 intended for quantitative analysis, quality control, and related biochemical research applications. D-Ribose(mixture of isomers)-13C5 is a version of D-Ribose(mixture of isomers) labeled with 13C. This compound serves as an energy booster and is a vital component of the sugar portion of ATP. It is widely utilized as a metabolic therapy supplement for chronic fatigue syndrome and myocardial energy metabolism. Additionally, D-Ribose(mixture of isomers) is active in protein glycation and can induce NF-κB inflammation in a RAGE-dependent manner.

Lidocaine-D10 (N,N-Diethyl-D10) (Standard) is a reference standard of Lidocaine-D10 (N,N-Diethyl-D10) intended for quantitative analysis, quality control, and related biochemical research applications. Lidocaine-d10 (N,N-diethyl-d10) is a deuterated compound of Lidocaine. Lidocaine has a CAS number of 137-58-6. Lidocaine is an amide local anesthetic with anti-inflammatory properties in vitro and in vivo. It has this functions perhaps due to an attenuation of intracellular adhesion molecule-1 (ICAM-1), pro-inflammatory cytokines, and reduction of neutrophils influx.

α-Lipoic Acid-D5 (Standard) is a reference standard of α-Lipoic Acid-D5 intended for quantitative analysis, quality control, and related biochemical research applications. α-Lipoic Acid-d5 is the deuterated form of α-Lipoic Acid. It serves as a significant antioxidant and an essential cofactor in mitochondrial enzyme complexes. α-Lipoic Acid has the ability to inhibit NF-κB-dependent HIV-1LTR activation and induces apoptosis in liver cancer cells (apoptosis) mediated by endoplasmic reticulum stress (ERS).

SjDX5-271v serves as the negative control for SjDX5-271. The compound SjDX5-271 is a 3 kDa peptide that inhibits the TLR4/MyD88/NF-κB signaling pathway. Additionally, SjDX5-271 induces cellular polarization, alleviates liver inflammation, and protects mice from hepatic ischemia-reperfusion injury.

(S)-NIK SMI1 is the isomer of NIK SMI1 and can be used as a control compound in experiments. NIK SMI1 serves as a potent and selective inhibitor of NF-κB-inducing kinase (NIK), effectively blocking the NIK-catalyzed hydrolysis of ATP to ADP, with an IC50 of 0.23±0.17 nM.