new delhi metallo-β-lactamase-1 (ndm-1)

Metallo-β-lactamase-IN-16 (compound 18), a sulfone-containing metallo-β-lactamase inhibitor, exhibits antimicrobial activity. It effectively inhibits various metallo-β-lactamases, including NDM-1 (New Delhi metallo-β-lactamase-1), IMP-1 (imipenemase-1), VIM-1 (Verona Integron-encoded Metallo-β-lactamase), and VIM-2. The IC50 values for these enzymes are 0.16 nM, 0.23 nM, 0.31 nM, and 1.0 nM respectively.

NDM-1 inhibitor-8 (Compound 18b) is a covalent inhibitor of New Delhi metallo-β-lactamase-1 (NDM-1), with an IC50 of 7.03 μM. It effectively inhibits resistant bacterial strains and demonstrates synergistic antibacterial effects when used in combination with Meropenem. In mouse models, NDM-1 inhibitor-8 exhibits anti-infective activity.

NDM-1 inhibitor-1 is an inhibitor of new delhi metallo-β-lactamase-1 (NDM-1).

NDM-1 inhibitor-2 is an inhibitor of new delhi metallo-β-lactamase-1 (NDM-1).

Captopril (SQ 14225) hydrochloride is an antihypertensive agent that is a thiol-containing, competitive, orally active angiotensin-converting enzyme (ACE) inhibitor with an IC50 of 0.025 μM, widely used in hypertension and congestive heart failure research. It is also a New Delhi metallo-β-lactamase-1 (NDM-1) inhibitor with an IC50 of 7.9 μM [1] [2] [3].

NDM-1 inhibitor-3 is a New Delhi Metallo-β-lactamase-1 (NDM-1) inhibitor (Ki : 4 μM) widely found in nature and is associated with antibiotic resistance.

Zndm19 is an inhibitor of New Delhi Metallo-β-lactamase-1 (NDM-1), utilized in researching drug-resistant bacterial infections [1].

Compound YJ196 (Compound 59) serves as an inhibitor of New Delhi Metallo-β-lactamase-1 (NDM-1) [1].

MBL-IN-3 (compound 72922413), a potent inhibitor of New Delhi metallo-β-lactamase-1 (NDM-1) with an IC50 value of 54±4 μM, effectively reduces the minimum inhibitory concentrations (MICs) of Meropenem against clinical isolates of E. coli and K. pneumoniae that express NDM-1. This compound is utilized in studies focused on antibiotic sensitizer research [1].