neutralizes interleukin-5

Mepolizumab (SB 240563) is a humanized monoclonal antibody that neutralizes IL-5, and can be utilized in research on severe eosinophilic asthma and eosinophilic granulomatosis with polyangiitis.

Anti-IL-5 Antibody (e.g., Mepolizumab) is a humanized monoclonal antibody that specifically neutralizes interleukin-5 (IL-5), effectively disrupting the signaling for eosinophil activation and survival by blocking the ligand-receptor interaction. In allergic inflammation models, this antibody significantly diminishes tissue eosinophil infiltration and alleviates airway hyperresponsiveness.