neuromedin b

Neuromedin B (NMB) is one of the bombesin (BN)-related peptides in mammals. It was originally purified from pig spinal cords, and it has been shown to be present in central nervous system as well as in gastrointestinal tract.

Neuromedin B-30 is a neuropeptide originally isolated from porcine brain and spinal cord and may exhibit activity in stimulating smooth muscle [1][2].

Bombesin receptor antagonist-1 (Example 32) is a bombesin receptor antagonist with Ki values of 0.17 nM for the neuromedin B (NMB receptor) and 20 nM for the gastrin-releasing peptide receptor (GRP receptor). Bombesin receptor antagonist-1 is utilized in the investigation of various diseases, including cancer, depression, and eating disorders.

BIM 23042 Acetate [D-Nal-Cys-Tyr- D-Trp-Lys-Val-Cys-Nal-NH2] is a selective antagonist of neuromedin B.

BA 1 TFA acts as a potent agonist for the bombesin (BB) family of receptors, exhibiting high affinity binding to Bombesin receptor subtype-3 (BRS3), gastrin-releasing peptide receptor (GRPR), and neuromedin B receptor (NMBR), with IC50 values of 6, 0.4, and 2.5 nM, respectively [1].

Bombesin is a 14-amino acid peptide originally isolated from the skin of the European fire-bellied toad (Bombina bombina). It has two known homologs in mammals called neuromedin B and gastrin-releasing peptide.

Bombesin acetate is a 14-amino acid peptide originally isolated from the skin of the European fire-bellied toad (Bombina bombina). It has two known homologs in mammals called neuromedin B and gastrin-releasing peptide.

[D-Cys6,Asn7,D-Ala11,Cys14]-Bombesin (6-14) is a synthetic peptide that functions as a non-selective bombesin receptor agonist. It exhibits pEC50 values of 8.06 for neuromedin B-preferential bombesin receptor (BB1), 8.69 for gastrin-releasing peptide-preferential bombesin receptor (BB2), and 6.71 for the orphan receptor (BB3). This compound is utilized in studies related to bombesin receptor-associated conditions, including cancer and neurological disorders.