neisseria gonorrhoeae

Acetazolamide (Diamox) is a Carbonic Anhydrase Inhibitor. The mechanism of action of acetazolamide is as a Carbonic Anhydrase Inhibitor. The chemical classification of acetazolamide is Sulfonamides.

Rosoxacin (Acrosoxacin) shows antibacterial activities against a broad spectrum of Gram-negative bacteria including Neisseria gonorrhoeae (MIC90 = 0.03mg/ml).

Meropenem (SM 7338) is a synthetic carbapenem antibiotic with broad-spectrum antibacterial activity. It exerts a bactericidal effect by inhibiting the synthesis of peptidoglycan in the bacterial cell wall and is active against a wide range of Gram-positive, Gram-negative, and anaerobic bacteria. Meropenem is active against both susceptible and resistant Neisseria gonorrhoeae (MIC values of 0.02–0.06 mg/mL), Haemophilus influenzae (MIC: 0.03–0.12 mg/mL), and Klebsiella pneumoniae (MIC: 0.015–0.12 mg/mL). Meropenem can be used for constructing bacterial infection models and screening for antimicrobial activity.

β-Lactamase-IN-1 (4-(1,3-dihydroxypropan-2-yl)-6-methoxypyrido[2,3-b]pyrazin-3-one) is a β-Lactamase inhibitor and targets the infection of Neisseria gonorrhoeae.

Meropenem (SM 7338) sodium is a broad-spectrum carbapenem antibiotic that exhibits activity against both susceptible and resistant strains of Neisseria gonorrhoeae (MIC values of 0.02-0.06 mg/mL), Haemophilus influenzae (MIC values of 0.03-0.12 mg/mL), and Moraxella catarrhalis (MIC values of 0.015-0.12 mg/mL).

ω-azido-C6 Ceramide reduces membrane potential and exhibits antibacterial activity against Neisseria, with a minimum inhibitory concentration (MIC) of 2 µg/mL for N. meningitidis MC58 and N. gonorrhoeae FA1090.

Apalcillin (PC-904) combined with Ro 48-1220 (a penicillin sulfone β-lactamase inhibitor) exhibits broad-spectrum activity against Gram-negative aerobic and anaerobic bacteria, excluding Klebsiella acid-producing strains. This combination shows strong efficacy against β-lactamase-producing Moraxella catarrhalis, Haemophilus influenzae, and Neisseria gonorrhoeae with an effective MIC of 11 μg/mL. Additionally, it inhibits Pseudomonas aeruginosa, Stenotrophomonas maltophilia, and Acinetobacter at low MICs (0.25 to 4 μg/mL). However, it has limited efficacy against oxacillin-resistant staphylococci and some Gram-positive bacteria. Apalcillin/Ro 48-1220's effectiveness against certain extended-spectrum β-lactamase-producing Escherichia coli is comparable to piperacillin/tazobactam, though it is less effective against SHV-type β-lactamases.

Debio 1453 is a potent bactericidal FabI inhibitor that is effective against Neisseria gonorrhoeae (IC50 = 0.6 nM) as well as its resistant strains. By inhibiting FabI and binding the non-mutatable NADH cofactor, Debio 1453 demonstrates a low propensity for resistance selection and effectively targets both planktonic and intracellular bacteria. It is capable of eradicating resistant Neisseria gonorrhoeae infections in a mouse vaginal infection model. Debio 1453 can be utilized in gonorrhea-related research.

Cefdaloxime, an orally active cephalosporin and the metabolite of HR-916 ester, exhibits broad-spectrum antibacterial activity. It is effective against various pathogens, including most members of the Enterobacteriaceae family, Staphylococcus species, Streptococcus species, Neisseria gonorrhoeae, Moraxella catarrhalis, and Haemophilus influenzae.

Nemonoxacin (TG-873870) is an orally available non-fluorinated quinolone antibiotic with broad-spectrum antimicrobial activity against staphylococci, streptococci, and enterococci, as well as against Neisseria gonorrhoeae and Haemophilus influenzae.Nemonoxacin is used in the study of bacterial infections and community-acquired pneumonia.

Mip-IN-1 (S,S-28i) is a novel inhibitor derived from rapamycin targeting the macrophage infectivity potentiator (Mip) proteins. It exhibits potent anti-enzymatic effects against Mip proteins from Neisseria meningitidis and Neisseria gonorrhoeae, significantly enhancing macrophage bactericidal efficacy [1].

Cefmatilen (S-1090) is an orally administered cephalosporin antibiotic that exhibits high activity against a variety of Gram-positive and Gram-negative bacteria, including Streptococcus pyogenes and Neisseria gonorrhoeae.

Penduletin (Standard) is a reference standard for research and analysis in studies involving Penduletin. Penduletin has anti-inflammatory,anti-tumor cells, and anti-bacterical activities,it inhibits growth of the Gram-negative pathogen neisseria gonorrhoeae. Penduletin has strong activity in vitro against EV71 with low cytotoxicity.

Penduletin has anti-inflammatory,anti-tumor cells, and anti-bacterical activities,it inhibits growth of the Gram-negative pathogen neisseria gonorrhoeae. Penduletin has strong activity in vitro against EV71 with low cytotoxicity.