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necrosulfonamide

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  • Inhibitors & Agonists
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Necrosulfonamide
(E)-Necrosulfonamide
T69041360614-48-7
(E)-Necrosulfonamide ((E)-Necrosulfonamide) is an inhibitor of necroptosis. Blocks mixed lineage kinase domain-like protein (MLKL), a critical substrate of receptor-interacting serine-threonine kinase 3 (RIP3) during necrosis. Prevents MLKL-RIP1-RIP3 necrosome complex from interacting with downstream necrosis effectors. Binds and inhibits gasdermin D. Inhibits pyroptosis.
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(E/Z)-Necrosulfonamide
T7129432531-71-0
(E Z)-Necrosulfonamide is a novel inhibitor of MLKL.
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