nebivolol

Nebivolol, a β1 receptor blocker with nitric oxide-potentiating vasodilatory effect, is used in treatment of hypertension, in Europe, it is also used for left ventricular failure. It is highly cardioselective under certain circumstances.

Nebivolol hydrochloride (R 065824 hydrochloride) is a cardioselective ADRENERGIC BETA-1 RECEPTOR ANTAGONIST (beta-blocker) that functions as a VASODILATOR through the endothelial L-arginine/ NITRIC OXIDE system. It is used to manage HYPERTENSION and chronic HEART FAILURE in elderly patients.

(Rac)-Nebivolol ((Rac)-R 065824) is a racemic isomer of Nebivolol, a selective β1-adrenergic receptor antagonist (IC50 = 0.8 nM). Nebivolol exhibits vasodilatory activity and can prevent Nox2 NADPH oxidase up-regulation and lipoperoxidation in early stages of ethanol-induced cardiac toxicity.

4-Hydroxy Nebivolol, a primary metabolite of Nebivolol, results from the enzymatic hydroxylation of Nebivolol by the cytochrome P450 (CYP) isoform CYP2D6.

N-Nitroso nebivolol (mixture of diastereomers) is a nitrosamine compound that exhibits mutagenic activity.

Nebivolol hydrochloride (Standard) is the standard substance of Nebivolol hydrochloride, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Nebivolol hydrochloride (R 065824 hydrochloride) is a cardioselective ADRENERGIC BETA-1 RECEPTOR ANTAGONIST (beta-blocker) that functions as a VASODILATOR through the endothelial L-arginine/ NITRIC OXIDE system. It is used to manage HYPERTENSION and chronic HEART FAILURE in elderly patients.

Dexnebivolol ( R67138) is an antagonist of the ß-adrenergic receptor and is an enantiomer of Nebivolol. Nebivolol is a β1 receptor blocker with nitric oxide enhancing vasodilation effect.

Levonebivolol (R 67145) is an enantiomer of nepirolol, a β1 blocker with nitric oxide vasodilators for the treatment of hypertension.