n,n-dimethylsphingosine

N,N-Dimethylsphingosine, an endogenous metabolite, is a potent competitive sphingosine kinase (SphK) inhibitor that selectively inhibits sphingosine phosphorylation without affecting its N-acylation.DMS is elevated in models of neuropathic pain, and may mediate mechanical nociception by increasing the release of IL-1β and MCP-1.

N,N-Dimethylsphingosine-13C2 is the 13C-labeled version of N,N-Dimethylsphingosine. This compound acts as a potent inhibitor of SphK (sphingosine kinase) and serves as an endogenous metabolite of sphingosine in various tissues and tumor cell lines.