mtor inhibitor2

mTOR inhibitor-2 is an inhibitor of selective and oral mTOR (IC50 of 7 nM).

PI3K/mTOR Inhibitor-2 is a potent pan inhibitor of PI3K and mTOR with IC50s of 3.4, 34, 16.1, and 4.7 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ, and mTOR, respectively. PI3K/mTOR Inhibitor-2 demonstrates antitumor activity.

mTORinhibitor-26 (Compound HPT-11) is an mTOR inhibitor with an IC50 of 0.7 nM. It effectively inhibits the proliferation of AML cell lines Molm-13 and MV-4-11. mTORinhibitor-26 exhibits antitumor activity and demonstrates good metabolic stability, making it promising for research in the field of cancer.

mTORinhibitor-27 (Compound 7e) is an inhibitor of mammalian target of rapamycin (mTOR) with an IC50 value of 5.47 μM. It can induce apoptosis in tumor cells and arrest the cell cycle in the S phase, thereby inhibiting cancer cell growth. mTORinhibitor-27 presents potential for research in cancer, including skin cancer.

mTORinhibitor-28 (SM-3) is a potent mTOR inhibitor that demonstrates inhibitory effects on A549, H292, and H460 cell lines, with IC50 values of 72.74, 67.66, and 43.24 μM, respectively.