ms432

MS432 is a highly selective PD0325901-based VHL-recruiting PROTAC degrader for MEK1 and MEK2.

Boc-11-aminoundecanoic acid is an alkyl/ether-based PROTAC linker used in the synthesis of [MS432].

Folate-MS432 is a PROTAC that degrades MEKs selectively in cancer cells via folate receptor-dependent pathways.

(Iso)-MS4322 ((Iso)-YS43-22) is a selective and potent protein arginine methyltransferase 5 (PRMT5) degrader with potential anticancer activity that effectively reduces PRMT5 protein levels in MCF-7 cells and inhibits the growth of a wide range of cancer cells.

Br-C10-methyl ester, a PROTAC linker characterized by its alkyl/ether composition, plays a crucial role in the synthesis of a series of PROTACs (MS432). This compound incorporates a dual-ligand system connected via a linker; notably, one ligand interacts with the VHL portion.

(S,R,S)-AHPC-Me-C10-Br is a chemically synthesized conjugate and ligand-linker for E3 ligase, consisting of MS432 for MEK1/2 inhibitors and a VHL E3 ligase linker.

(S,R,S)-AHPC-Me-C10-NH2 is a synthesized chemical compound incorporating a VHL ligand and a linker, serving as an E3 ligase ligand-linker conjugate. It is utilized in PROTAC MS432[1].