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By Target- Kras
- Ras(1)
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Results for "
mrtx-1257
" in TargetMol Product Catalog.- Inhibitors & Agonists1
- MRTX-1257T161432206736-04-9MRTX-1257 is a selective, irreversible, and covalent inhibitor of KRAS G12C with an IC50 of 900 pM for KRAS-dependent ERK phosphorylation in H358 cells. MRTX-1257 demonstrated 31% bioavailability in the mouse, with free fraction exposures well above cellular potency, and 77% target engagement in a PK/PD experiment.
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