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By Target- Mitochondrial Metabolism
- Autophagy(1)
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Results for "
mpp+ iodide
" in TargetMol Product Catalog- Inhibitors & Agonists2
- Isotope Products1
MPP+ iodide
Cited
T916936913-39-0
MPP+ iodide, the metabolite of a neurotoxin MPTP, causes symptom of Parkinson's disease (PD) in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ induces dopamine transporter (DAT) externalization in dopaminergic (DA) neurons, but internalization of serotonin transporter (SERT) in serotonergic (5-HT) neurons. MPP+ induces autophagic cell death in SH-SY5Y cells.
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CitedMPP+-d3 iodide
TMID-0362207556-07-8
MPP+-d3 (iodide) is the deuterated variant of MPP+ (iodide). MPP+ iodide is a toxic metabolite of the neurotoxin MPTP, which induces Parkinsonian symptoms in animal models by selectively destroying dopaminergic neurons in the substantia nigra. It is absorbed into dopaminergic neurons via the dopamine transporter and exerts its neurotoxic effects by interfering with mitochondrial respiratory chain complex I. Additionally, MPP+ iodide is a high-affinity substrate for the serotonin transporter (SERT).
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